The influence of valproic acid on salivary pH in children with cerebral palsy.
Identifieur interne : 000404 ( Main/Exploration ); précédent : 000403; suivant : 000405The influence of valproic acid on salivary pH in children with cerebral palsy.
Auteurs : Walter Luiz Siqueira [États-Unis] ; Maria Teresa Botti Rodrigues Santos ; Satheesh Elangovan ; Alyne Simoes ; José NicolauSource :
- Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry [ 0275-1879 ]
Descripteurs français
- KwdFr :
- Acide valproïque (métabolisme), Analyse de variance (MeSH), Anticonvulsivants (métabolisme), Concentration en ions d'hydrogène (effets des médicaments et des substances chimiques), Enfant (MeSH), Facteurs temps (MeSH), Humains (MeSH), Paralysie cérébrale (traitement médicamenteux), Saccharose (administration et posologie), Salive (composition chimique), Salive (effets des médicaments et des substances chimiques), Études croisées (MeSH).
- MESH :
- administration et posologie : Saccharose.
- composition chimique : Salive.
- effets des médicaments et des substances chimiques : Concentration en ions d'hydrogène, Salive.
- métabolisme : Acide valproïque, Anticonvulsivants.
- traitement médicamenteux : Paralysie cérébrale.
- Analyse de variance, Enfant, Facteurs temps, Humains, Études croisées.
English descriptors
- KwdEn :
- Analysis of Variance (MeSH), Anticonvulsants (metabolism), Cerebral Palsy (drug therapy), Child (MeSH), Cross-Over Studies (MeSH), Humans (MeSH), Hydrogen-Ion Concentration (drug effects), Saliva (chemistry), Saliva (drug effects), Sucrose (administration & dosage), Time Factors (MeSH), Valproic Acid (metabolism).
- MESH :
- chemical , administration & dosage : Sucrose.
- chemical , metabolism : Anticonvulsants, Valproic Acid.
- chemistry : Saliva.
- drug effects : Hydrogen-Ion Concentration, Saliva.
- drug therapy : Cerebral Palsy.
- Analysis of Variance, Child, Cross-Over Studies, Humans, Time Factors.
Abstract
The purpose of this open-label, crossover study was to measure salivary pH after the oral administration of distilled water, a 10% sucrose solution, and valproic acid to a population of 10 children with cerebral palsy. Salivary pH was measured just prior to giving the solutions and then every five minutes for 60 minutes. The critical pH was defined at 5.5, below which dental demineralization occurs. In this population, valproic acid decreased salivary pH to below the critical pH for an extended period of time (mean = 4.32 at 20 minutes) when compared to mean salivary pH after administration of distilled water (7.11 at 20 minutes) and a 10% sucrose solution (5.96 at 20 minutes). Recovery from this low pH to above the critical level did not occur until after 50 minutes and furthermore did not recover to baseline, neutral levels, for the duration of this study (60 minutes). Our results suggest that children with cerebral palsy, a population with a tendency toward reduced salivary function, have a compromised ability to buffer the oral administration of an exogenous acid. This can result in an increased susceptibility to demineralization and caries of the teeth.
DOI: 10.1111/j.1754-4505.2007.tb00330.x
PubMed: 17539222
Affiliations:
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Santos</name></author><author><name sortKey="Elangovan, Satheesh" sort="Elangovan, Satheesh" uniqKey="Elangovan S" first="Satheesh" last="Elangovan">Satheesh Elangovan</name></author><author><name sortKey="Simoes, Alyne" sort="Simoes, Alyne" uniqKey="Simoes A" first="Alyne" last="Simoes">Alyne Simoes</name></author><author><name sortKey="Nicolau, Jose" sort="Nicolau, Jose" uniqKey="Nicolau J" first="José" last="Nicolau">José Nicolau</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007 Mar-Apr</date><idno type="RBID">pubmed:17539222</idno><idno type="pmid">17539222</idno><idno type="doi">10.1111/j.1754-4505.2007.tb00330.x</idno><idno type="wicri:Area/Main/Corpus">000416</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000416</idno><idno type="wicri:Area/Main/Curation">000416</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000416</idno><idno 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last="Santos">Maria Teresa Botti Rodrigues Santos</name></author><author><name sortKey="Elangovan, Satheesh" sort="Elangovan, Satheesh" uniqKey="Elangovan S" first="Satheesh" last="Elangovan">Satheesh Elangovan</name></author><author><name sortKey="Simoes, Alyne" sort="Simoes, Alyne" uniqKey="Simoes A" first="Alyne" last="Simoes">Alyne Simoes</name></author><author><name sortKey="Nicolau, Jose" sort="Nicolau, Jose" uniqKey="Nicolau J" first="José" last="Nicolau">José Nicolau</name></author></analytic><series><title level="j">Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry</title><idno type="ISSN">0275-1879</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis of Variance (MeSH)</term><term>Anticonvulsants (metabolism)</term><term>Cerebral Palsy (drug therapy)</term><term>Child (MeSH)</term><term>Cross-Over Studies (MeSH)</term><term>Humans (MeSH)</term><term>Hydrogen-Ion Concentration (drug effects)</term><term>Saliva (chemistry)</term><term>Saliva (drug effects)</term><term>Sucrose (administration & dosage)</term><term>Time Factors (MeSH)</term><term>Valproic Acid (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide valproïque (métabolisme)</term><term>Analyse de variance (MeSH)</term><term>Anticonvulsivants (métabolisme)</term><term>Concentration en ions d'hydrogène (effets des médicaments et des substances chimiques)</term><term>Enfant (MeSH)</term><term>Facteurs temps (MeSH)</term><term>Humains (MeSH)</term><term>Paralysie cérébrale (traitement médicamenteux)</term><term>Saccharose (administration et posologie)</term><term>Salive (composition chimique)</term><term>Salive (effets des médicaments et des substances chimiques)</term><term>Études croisées (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Sucrose</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Anticonvulsants</term><term>Valproic Acid</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Saccharose</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Saliva</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Salive</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Hydrogen-Ion Concentration</term><term>Saliva</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Cerebral Palsy</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Concentration en ions d'hydrogène</term><term>Salive</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Acide valproïque</term><term>Anticonvulsivants</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Paralysie cérébrale</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term><term>Child</term><term>Cross-Over Studies</term><term>Humans</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de variance</term><term>Enfant</term><term>Facteurs temps</term><term>Humains</term><term>Études croisées</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The purpose of this open-label, crossover study was to measure salivary pH after the oral administration of distilled water, a 10% sucrose solution, and valproic acid to a population of 10 children with cerebral palsy. Salivary pH was measured just prior to giving the solutions and then every five minutes for 60 minutes. The critical pH was defined at 5.5, below which dental demineralization occurs. In this population, valproic acid decreased salivary pH to below the critical pH for an extended period of time (mean = 4.32 at 20 minutes) when compared to mean salivary pH after administration of distilled water (7.11 at 20 minutes) and a 10% sucrose solution (5.96 at 20 minutes). Recovery from this low pH to above the critical level did not occur until after 50 minutes and furthermore did not recover to baseline, neutral levels, for the duration of this study (60 minutes). Our results suggest that children with cerebral palsy, a population with a tendency toward reduced salivary function, have a compromised ability to buffer the oral administration of an exogenous acid. This can result in an increased susceptibility to demineralization and caries of the teeth.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17539222</PMID><DateCompleted><Year>2007</Year><Month>08</Month><Day>23</Day></DateCompleted><DateRevised><Year>2019</Year><Month>10</Month><Day>26</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0275-1879</ISSN><JournalIssue CitedMedium="Print"><Volume>27</Volume><Issue>2</Issue><PubDate><MedlineDate>2007 Mar-Apr</MedlineDate></PubDate></JournalIssue><Title>Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry</Title><ISOAbbreviation>Spec Care Dentist</ISOAbbreviation></Journal><ArticleTitle>The influence of valproic acid on salivary pH in children with cerebral palsy.</ArticleTitle><Pagination><MedlinePgn>64-6</MedlinePgn></Pagination><Abstract><AbstractText>The purpose of this open-label, crossover study was to measure salivary pH after the oral administration of distilled water, a 10% sucrose solution, and valproic acid to a population of 10 children with cerebral palsy. Salivary pH was measured just prior to giving the solutions and then every five minutes for 60 minutes. The critical pH was defined at 5.5, below which dental demineralization occurs. In this population, valproic acid decreased salivary pH to below the critical pH for an extended period of time (mean = 4.32 at 20 minutes) when compared to mean salivary pH after administration of distilled water (7.11 at 20 minutes) and a 10% sucrose solution (5.96 at 20 minutes). Recovery from this low pH to above the critical level did not occur until after 50 minutes and furthermore did not recover to baseline, neutral levels, for the duration of this study (60 minutes). Our results suggest that children with cerebral palsy, a population with a tendency toward reduced salivary function, have a compromised ability to buffer the oral administration of an exogenous acid. This can result in an increased susceptibility to demineralization and caries of the teeth.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Siqueira</LastName><ForeName>Walter Luiz</ForeName><Initials>WL</Initials><AffiliationInfo><Affiliation>Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, MA, USA. wlsiqueira@gmail.com</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Santos</LastName><ForeName>Maria Teresa Botti Rodrigues</ForeName><Initials>MT</Initials></Author><Author ValidYN="Y"><LastName>Elangovan</LastName><ForeName>Satheesh</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Simoes</LastName><ForeName>Alyne</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Nicolau</LastName><ForeName>José</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal 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UI="D002547" MajorTopicYN="N">Cerebral Palsy</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018592" MajorTopicYN="N">Cross-Over Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006863" MajorTopicYN="N">Hydrogen-Ion Concentration</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012463" MajorTopicYN="N">Saliva</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013395" MajorTopicYN="N">Sucrose</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014635" MajorTopicYN="N">Valproic Acid</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>6</Month><Day>2</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>8</Month><Day>24</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>6</Month><Day>2</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">17539222</ArticleId><ArticleId IdType="doi">10.1111/j.1754-4505.2007.tb00330.x</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li></region></list><tree><noCountry><name sortKey="Elangovan, Satheesh" sort="Elangovan, Satheesh" uniqKey="Elangovan S" first="Satheesh" last="Elangovan">Satheesh Elangovan</name><name sortKey="Nicolau, Jose" sort="Nicolau, Jose" uniqKey="Nicolau J" first="José" last="Nicolau">José Nicolau</name><name sortKey="Santos, Maria Teresa Botti Rodrigues" sort="Santos, Maria Teresa Botti Rodrigues" uniqKey="Santos M" first="Maria Teresa Botti Rodrigues" last="Santos">Maria Teresa Botti Rodrigues Santos</name><name sortKey="Simoes, Alyne" sort="Simoes, Alyne" uniqKey="Simoes A" first="Alyne" last="Simoes">Alyne Simoes</name></noCountry><country name="États-Unis"><region name="Massachusetts"><name sortKey="Siqueira, Walter Luiz" sort="Siqueira, Walter Luiz" uniqKey="Siqueira W" first="Walter Luiz" 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